About Dr Brian Ang

Glaucoma Treatment With Istent Implantation

Why is implantation of the iStent necessary?

The iStent is implanted to decrease eye pressure. It can be implanted on its own, or combined at the same time as cataract surgery for patients who have both cataract and glaucoma. In some patients, the stent reduces the number of pressure-lowering eye drops used. In some cases, it may be possible to stop all pressure-lowering eye drops completely.

The lens is the middle window inside the eye that focuses light entering the eye. As you age, your lens becomes gradually more cloudy – this is called a cataract. As the cataract progresses, you may experience worsening vision and increasing glare. During cataract surgery, the cloudy lens inside your eye is removed and replaced with an artificial clear lens implant. The lens implant remains in the eye permanently.

(Images adapted from the internet)

Fluid in the eye (aqueous) is produced by the ciliary body, and drains out through the trabecular meshwork (drainage pathway) in the drainage angle. Sometimes the trabecular meshwork no longer copes, preventing aqueous from draining out easily. This causes pressure to build up in the eyeball. When the pressure in the eye is too high, it can cause optic nerve damage and permanent vision loss – this is called glaucoma.

See Related: 

Surgical treatments for glaucoma

Surgical treatments for cataract

What does the iStent do?

The iStent is one of the glaucoma surgery techniques called minimally invasive glaucoma surgery (MIGS). In contrast to traditional glaucoma surgery, MIGS is quicker and easier to perform and has less risk of complications, but has reduced overall pressure control.

The iStent Inject is is made of titanium and only measures 0.36 mm long. Implantation of the iStent Inject involves puncturing the stent through the trabecular meshwork. This creates an opening in the trabecular meshwork which allows aqueous to drain out in a controlled manner, thereby reducing eye pressure.

There is no change to the way the cataract surgery is performed. Two stents are implanted into the trabecular meshwork after the lens implant has been inserted into the eye. This adds around 5 to 10 minutes to the overall cataract surgery time.

See Related: 

Hydrus microstent implantation for glaucoma

CyPass micro-stent implantation for glaucoma

What are the potential risks?

The iStent is very safe. Apart from the usual risks associated with cataract surgery, additional risks specific to the iStent Inject are rare. These include:

● Bleeding into the eye. This is generally mild and settles over a few days.
   Rarely the bleeding can be severe, causing blurred vision for a few months.
● Stent implantation issues, such as implantation at a non-ideal location,
   depth or angle. Rarely, the stent may become dislodged from its
   implanted position. No harm or damage will be caused to the eye, so
   usually no additional procedure is needed to reposition or remove the stent.
   However, you may need to restart your glaucoma eye drops.
● Failure to work. It is possible that the iStent Inject may not work in your eye
   despite successful and uncomplicated implantation. Sometimes the stent
   works well initially, but the pressure gradually increases over time. If this
   occurs, you may need to restart your glaucoma eye drops.
● Problems with the MRI may occur if you require an MRI scan above the 3
   Tesla setting. There is no problem with MRI scans up to 3 Tesla.
● Infection inside the eye (endophthalmitis). This is the most serious
   complication, and can cause permanent sight loss despite treatment
   with antibiotics and surgery.

See Related: Risks and complications of glaucoma surgery

What should I expect?


(Image adapted from the internet)

IStent Inject implantation is a hospital-based day case procedure performed under local anesthetic. The operation is usually performed one eye at a time.

Before and during surgery:

All the instructions before and after surgery are the same as for cataract surgery. All the precautions and surgical steps taken are the same as for cataract surgery. The following are the extra steps that will occur during iStent Inject implantation:

● You will be asked to rotate your head to one side.
● A contact lens will be placed on your eye.
● The stents will be implanted into the trabecular meshwork.

After surgery:

After iStent implantation, a pad and shield will be placed over your eye. The pad and shield can be removed the next day, and you can start your normal postoperative eye drops, usually a steroid (Prednisolone or Dexamethasone) 4 times daily for 3 to 4 weeks.

You will usually be reviewed the day after surgery to check the positioning of the stents and your eye pressure. The reduction in the eye pressure with the iStent Inject may not be immediate, so you may still have to continue your usual pressure-lowering eye drops for a few weeks.

Over the next few days, you may experience blurriness, discomfort, sensitivity to light, and blood around the eye. This will gradually improve with the eye drops. As with routine cataract surgery, it can take a week or two before you notice any improvement in your vision.

Please contact the clinic immediately if you experience pain or a sharp drop in vision.

See Related: 

Patient guide to cataract surgery

Natural remedies for glaucoma

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